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Lame dog and infection11/5/2023 ![]() The profile of breeds affected by panosteitis is similar to that of those affected by von Willebrand’s disease and individuals with panosteitis often have an abnormality of blood clotting factor VIII, giving additional credence to the proposal that genetic influences play a major part. The disease might have genetic basis, since some breeds of dogs (including GSDs and Bassett hounds) are predisposed to the disease. As the bone is rigid this extra volume of fluid causes compression of blood vessels and to inadequate blood supply to the tissues of the bone, leading to inflammation ![]() The theory is that high protein levels lead to oedema (fluid collection and retention) within the tissues of the medullary cavity. A more recent suggestion is that the disease is related to use of high-protein/ high-calorie commercial diets. Ultimately, as the disease process subsides, this new bone is removed as part of the normal bone remodelling processes and the fatty marrow regenerates. In animals affected with panosteitis, the fat cells of the yellow marrow degenerate, inflammation occurs and this tissue is replaced with fibrous tissue, which in turn is calcified and turned into spongy bone tissue, as osteoblasts, osteoclasts and fibroblasts (fibrous tissue-producing cells) are activated. The disease is usually self-limiting and spontaneously regresses once sexual maturity is reached, although some individuals may be affected up to middle-age. Males seem to be affected more often than females, although either sex can develop panosteitis. Dogs may also be anorexic, lethargic and have a raised body temperature.ĭogs are usually affected between 5 and 14 months of age, but the first symptoms may occur as early as 2 months of age or as late as 18 months of age. The most common bone that is affected is the humerus (upper arm), but panosteitis may also be found in the radius and ulna (the foreleg), the femur (thigh) and/or the tibia (lower rear leg). Considering its nature, it has cycling periods of worsening symptoms followed by periods of improvement. The pain is likely caused by increased pressure within the bone, and/or by stimulation of pain receptors in the periosteum, or outer, soft tissue lining of the bone. ![]() It can occur in any bone which contains significant volumes of bone marrow, long bone shafts being the most common sites.Īffected GSDs will have significant episodes of bone pain, which can be severe, and exhibit as lameness, often described as a “shifting lameness” (lameness first affecting one leg and then another). Panosteitis, a common disease of juvenile dogs, is characterized by inflammation of the fatty bone marrow with subsequent effects on the surrounding bone. ![]() X-rays from the limbs showed a characteristic increase in the density of the affected bones, which made the diagnosis of panosteitis. He showed massive pain on palpation and exertion of pressure on both hind limbs. A 10-month-old black German shepherd dog manifesting shifting lameness and lack of appetite.
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